Sugar vs Artificial Sweeteners
Neither? Can that be the answer? Both sugar and artificial sweeteners show addictive properties so it is hard to say if one is better or worse. However, the more research that comes out about artificial sweeteners, the more I want to shy away.
Let's talk about sugar first. Research suggests:
- Sugar consumption activates the brain-reward system (mesolimbic-dopamine system). When this system fires, it reinforces behaviors.
- Repeated activation of the reward pathway by drugs or by eating lots of sugary foods causes the brain to adapt to frequent stimulation, leading to a sort of tolerance (neuroplasticity). In the case of sweet foods, this means we need to eat more to get the same rewarding feeling — a classic feature of addiction.
- People who consume high amounts of sugar, report craving more sugar.
- High sugar diets actually change the hippocampus (the part of the brain responsible for encoding memories) which compromises memory formation.
- A highly publicized (and controversial) 2017 study suggested that rats prefer sugar to cocaine.
- The average American consumes 17 tsp (68 g) of added sugar daily, 2-3x the recommended amount. (WHO recommends <5% (6 tsp), DGA recommends <10% (12 tsp) of calories come from added sugars. One can of soda has 10 tsp of sugar. A Starbucks Java Chip Frappacino has 16 tsp or sugar in it.
- Excessive sugar can alter (numb) taste perception.
*1 tsp sugar = 4 grams (4 kcal/1gram of CHO)
What about artificial sweeteners? Research suggests:
- The FDA has approved five artificial sweeteners: saccharin, acesulfame, aspartame, neotame, and sucralose. It has also approved one natural low-calorie sweetener, stevia.
- WHO (World Health Organization) does NOT recommend AS for weight control (statement released in 2023, caused a HUGE stir in the food industry).
- AS exposure is linked to type 2 diabetes, obesity and heart disease (also linked to obesity).
- Brain imaging shows that AS affect brain regions in areas responsible for sweetness and rewards resulting in increased desire for calorie dense foods.
- Brain changes w/ AS consumption decrease sweetness satisfaction
- Prolonged AS consumption increases number of GLUT4 transporters meaning that when real sugar is consumed, more is taken into the cells.
- AS affect the gut microbiome in negative ways. Even though they are not metabolized per say, they create metabolites that can negatively affect brain function with regard to cognitive decline and dementia.
- Preliminary animal studies indicate that AS are addictive.
- Although sucralose is rated as heat stable, more recent studies call this into question, which is problematic considering that many commercially baked products contain sucralose.
Exercise is the best medicine
--Hippocrates
Nutritious Foundations









